MASP2

Also known as MAP19, MASP-2, MASP1P1, sMAP, mannan binding lectin serine peptidase 2, Mannan-binding lectin serine protease 2, MBL associated serine protease 2, MAP-2

protein-coding gene in the species Homo sapiens

Gene data

MASP2

Name: MBL associated serine protease 2
Type: protein-coding
Aliases: MAP-2, MAP19, MASP-2, MASP1P1, sMAP

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].

via MyGene.info

Gene · Ensembl

MBL associated serine protease 2

Symbol: MASP2
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:11,022,009-11,047,273
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: PDB 1q3x EBI.jpg

Show 6 more facts

HomoloGene ID: 4819
exact match: identifiers.org/ncbigene/10747
genomic end: 11047239
genomic start: 11086580
cytogenetic location: 1p36.22
Commons category: Mannan-binding lectin serine protease 2 (MASP-2), catalytic domain

Sources (3)

via Wikidata · CC0