coagulation factor X

Protein · UniProt

Coagulation factor X

Gene

F10

Organism

Homo sapiens (Human)

Length

488 aa

Molecular mass

54,732 Da

Evidence

1: Evidence at protein level

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (PubMed:22409427, PubMed:39880037). Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner (PubMed:24041930, PubMed:30568593, PubMed:34831181, PubMed:18202198). Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells (PubMed:35738824). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CC…

• Blood coagulation factor X: molecular biology, inherited disease, and engineered therapeutics.Journal of thrombosis and thrombolysis · 2021
• Factor X Friuli Coagulation Disorder: Almost 50 Years Later.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018
• Autoimmune Coagulation Factor X Deficiency as a Rare Acquired Hemorrhagic Disorder: A Literature Review.Thrombosis and haemostasis · 2022
• Factor X deficiency.Blood reviews · 2002
• Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent.Blood cells, molecules & diseases · 2021

via PubMed

• COMPLETED
  Are There Differences Between Carriers of Haemophilia A and B?Cliniques universitaires Saint-Luc- Université Catholique de Louvain · NCT05217992
• PHASE1COMPLETED
  Study of FVIIa Variant BAY86-6150 (B0189) in Subjects With Moderate or Severe Hemophilia Types A or B With or Without InhibitorsBayer · NCT01921855
• COMPLETED
  Study of Prophylaxis, ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated With ADVATE or RIXUBISBaxalta now part of Shire · NCT02190149
• PHASE1/PHASE2COMPLETED
  Trial of AAV5-hFIX in Severe or Moderately Severe Hemophilia BCSL Behring · NCT02396342
• NACOMPLETED
  Gene Therapy for Chinese Hemophilia BInstitute of Hematology & Blood Diseases Hospital, China · NCT04135300
• PHASE1COMPLETED
  Safety and Mode of Action of a Single Dose and Multiple Doses of Long Acting Activated Recombinant Human Factor VII in Patients With Haemophilia A and BNovo Nordisk A/S · NCT00922792

via ClinicalTrials.gov

Wikidata facts

Image

Protein F10 PDB 1c5m.png

via Wikidata · CC0