coagulation factor III, tissue factor

Protein · UniProt

Tissue factor

Gene

F3

Organism

Homo sapiens (Human)

Length

295 aa

Molecular mass

33,068 Da

Evidence

1: Evidence at protein level

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade

• Tissue factor pathway.Bailliere's clinical haematology · 1994
• Tissue Factor Driven Coagulation and Inflammation in Lung Injury: Insights From In Vitro and In Vivo Models.IUBMB life · 2025
• Tissue factor.The international journal of biochemistry & cell biology · 1998
• Tissue factor controversies.Thrombosis research · 2012
• Tissue factor as a link between inflammation and coagulation.Trends in cardiovascular medicine · 2016

via PubMed

• PHASE2COMPLETED
  Study of PER977 Administered to Subjects With Steady State Edoxaban Dosing and Re-anticoagulation With EdoxabanPerosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc. · NCT02207257
• PHASE1/PHASE2SUSPENDED
  Safety Study of Recombinant NAPc2 to Prevent Tumor Progression and Metastases in Metastatic Colon CancerARCA Biopharma, Inc. · NCT00443573
• PHASE1WITHDRAWN
  Study to Test the Safety of an Investigational Drug Given Repeatedly to Adult Men With Severe HemophiliaBayer · NCT03996486
• COMPLETED
  Tissue Factor Pathway Inhibitor (TFPI) and Haemorrhagic Manifestations in Haemophilia A and B PatientsCentre Hospitalier Universitaire de Saint Etienne · NCT02540187
• COMPLETED
  TIFACT Study - Tissue Factor Expression by Adipose Tissue in Extremely Obese Subjects.Assistance Publique - Hôpitaux de Paris · NCT00379704
• COMPLETED
  The Roles of Tissue Factor in Malignant GliomasOntario Clinical Oncology Group (OCOG) · NCT00201903

via ClinicalTrials.gov