IL3RA
Sign in to saveAlso known as CD123, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, interleukin 3 receptor subunit alpha
Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene.
Gene data
IL3RA- Name
- interleukin 3 receptor subunit alpha
- Type
- protein-coding
- Chromosome
- X
- Position
- 1,335,025–1,382,689 (+)
- Aliases
- CD123, IL-3R-alpha, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra
- Ensembl
- ENSG00000185291
- RefSeq RNA
- NM_001267713.2, NM_002183.4, XM_005274431.6, XM_005274432.2, XM_005274780.6
- RefSeq protein
- NP_001254642.1, NP_002174.1, XP_005274488.1, XP_005274489.1, XP_005274837.1
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
interleukin 3 receptor subunit alpha
- Symbol
- IL3RA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:1,335,025-1,382,689
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- CD123.png
Show 8 more facts
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3563
- HomoloGene ID
- 48088
- chromosome
- human X chromosome
- genomic end
- 1501578
- genomic start
- 1455509
- cytogenetic location
- X;Y
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene.
== Function == The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.
Excerpted from Wikipedia’s “IL3RA” article, available under the CC BY-SA 4.0 licence.