phenindione

Also known as Dindevan®, phenylindanedione, 2-Phenyl-1,3-indandione, PID, 2-phenyl-1,3-diketohydrindene, 2-phenyl-1,3(2H)-Indenedione, Phenindion, Phenindionum

Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

In the Vinony graph

Within Vinony's link graph, phenindione is referenced by 121 other articles, and connects out to hirudin, coagulation factor X and ximelagatran.

Vinony files it under 1,3-Indandiones, Drugs with no legal status and ECHA InfoCard ID from Wikidata.

Its subject is documented across 14 Wikipedia language editions.

Chemical data

Formula: C15H10O2
Molecular weight: 222.24 g/mol
IUPAC name: 2-phenylindene-1,3-dione
SMILES: C1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O
InChIKey: NFBAXHOPROOJAW-UHFFFAOYSA-N
XLogP: 2.9
Polar surface area: 34.1 Å²
H-bond donors: 0
H-bond acceptors: 2
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1982
Admin. routes: oral
Indications: Recurrent thrombophlebitis, pregnancy

via ChEMBL · EBI

Research

926 papers

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 222.06808
Has use: medication

Show 7 more facts

chemical formula: C₁₅H₁₀O₂
canonical SMILES: C1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O
defined daily dose: 0.1
World Health Organisation international non-proprietary name: phenindione
subject has role: anticoagulant
Commons category: Phenindione
significant drug interaction: (S)-duloxetine

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
External links

Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

Phenindione was introduced in the early 1950s. It acts similar to warfarin, but it has been associated with hypersensitivity reactions, so it is rarely used and warfarin is preferred.

Excerpted from Wikipedia’s “phenindione” article, available under the CC BY-SA 4.0 licence.