Structure via PubChem · Public domain (PubChem)
ramatroban
Sign in to saveAlso known as BAY U3405, BAY-U-3405, baynas, EN-137774
Ramatroban (INN; also known as BAY u3405) is a thromboxane receptor antagonist. It is also a DP2 receptor antagonist.
Chemical data
- Formula
- C21H21FN2O4S
- Molecular weight
- 416.5 g/mol
- IUPAC name
- 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid
- SMILES
- C1CC2=C(C[C@@H]1NS(=O)(=O)C3=CC=C(C=C3)F)C4=CC=CC=C4N2CCC(=O)O
- InChIKey
- LDXDSHIEDAPSSA-OAHLLOKOSA-N
- XLogP
- 2.9
- Polar surface area
- 96.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2000
- Admin. routes
- oral
- Indications
- asthma, COVID-19
via ChEMBL · EBI
Research
161 papers- Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath.Expert opinion on therapeutic targets · 2022
- Ramatroban-Based Analogues Containing Fluorine Group as Potential (18)F-Labeled Positron Emission Tomography (PET) G-Protein Coupled Receptor 44 (GPR44) Tracers.Molecules (Basel, Switzerland) · 2021
- Ramatroban (BAY u 3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor.Cardiovascular drug reviews · 2004
- Ramatroban as a Novel Immunotherapy for COVID-19.Journal of molecular and genetic medicine : an international journal of biomedical research · 2020
- [Ramatroban (Baynas): a review of its pharmacological and clinical profile].Nihon yakurigaku zasshi. Folia pharmacologica Japonica · 2001
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 416.120606
Show 7 more facts
- isomeric SMILES
- C1CC2=C(C[C@@H]1NS(=O)(=O)C3=CC=C(C=C3)F)C4=CC=CC=C4N2CCC(=O)O
- chemical formula
- C₂₁H₂₁FN₂O₄S
- canonical SMILES
- C1CC2=C(CC1NS(=O)(=O)C3=CC=C(C=C3)F)C4=CC=CC=C4N2CCC(=O)O
- physically interacts with
- Thromboxane A2 receptor
- subject has role
- platelet aggregation inhibitors
- medical condition treated
- allergic rhinitis
- Commons category
- Ramatroban
Sources (5)
via Wikidata · CC0
~3 min read
Encyclopedic overview
4 sectionsContents
- Synthesis
- See also
- References
- External links
{{Infobox drug | IUPAC_name = 3-((3R)-3-{[(4-fluorophenyl)sulfonyl]amino}-1,2,3,4-tetrahydro-9H-carbazol-9-yl)propanoic acid | image = Ramatroban.svg | image_class = skin-invert-image | alt = | caption =
| pronounce = | tradename = Baynas | Drugs.com = | MedlinePlus = | pregnancy_category = | routes_of_administration = Oral (tablets) | legal_status = Rx-only (JP)
Excerpted from Wikipedia’s “ramatroban” article, available under the CC BY-SA 4.0 licence.