benorilate
Sign in to saveBenorilate (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.
Research
18 papers- [Long-term toxicity of benorylate].Zeitschrift fur Rheumatologie · 1975
- Determination of benorilate in pharmaceutical formulations and its metabolite in urine at carbon paste electrode modified by silver nanoparticles.Talanta · 2005
- [Identification and quantitation of impurities from benorilate (Salipran) by high-performance liquid chromatography (author's transl)].Journal of chromatography · 1977
- Descriptors for some compounds with pharmacological activity; calculation of properties.International journal of pharmaceutics · 2022
- [Studies on formulation and bioavailability of benorilate tablets].Yao xue xue bao = Acta pharmaceutica Sinica · 1994
via PubMed
Wikidata facts
- Mass
- 313.095
Show 4 more facts
- chemical formula
- C₁₇H₁₅NO₅
- canonical SMILES
- CC(=O)NC1=CC=C(C=C1)OC(=O)C2=CC=CC=C2OC(=O)C
- isomeric SMILES
- C/C(=N\C1=CC=C(C=C1)OC(=O)C2=CC=CC=C2OC(=O)C)/O
- Commons category
- Benorilate
Sources (2)
via Wikidata · CC0
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Article
2 sectionsContents
- Synthesis
- References
Benorilate (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.
==Synthesis== Acetylsalicoyl chloride (1) condenses with paracetamol (2) to give benorilate (3).
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