Structure via PubChem · Public domain (PubChem)
travoprost
Sign in to saveAlso known as AL-6221, Travatan®, isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate, Travoprostum, Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1e,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate
Travoprost, sold under the brand name Travatan among others, is a medication used to treat high pressure inside the eye including glaucoma. Specifically it is used for open angle glaucoma when other agents are not sufficient. It is used as an eye drop. Effects generally occur within two hours.
Chemical data
- Formula
- C26H35F3O6
- Molecular weight
- 500.5 g/mol
- IUPAC name
- propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
- SMILES
- CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](COC2=CC=CC(=C2)C(F)(F)F)O)O)O
- InChIKey
- MKPLKVHSHYCHOC-AHTXBMBWSA-N
- XLogP
- 4.1
- Polar surface area
- 96.2 Ų
- H-bond donors
- 3
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2001
- Admin. routes
- topical
- Indications
- open-angle glaucoma, ocular hypertension, exfoliation syndrome, glaucoma
via ChEMBL · EBI
Wikidata facts
- Subclass of
- prostaglandins
- Mass
- 500.238573
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₆H₃₅F₃O₆
- isomeric SMILES
- CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](COC2=CC=CC(=C2)C(F)(F)F)O)O)O
- canonical SMILES
- CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC(=C2)C(F)(F)F)O)O)O
- World Health Organisation international non-proprietary name
- travoprost
- subject has role
- antihypertensive drug
- Commons category
- Travoprost
Sources (7)
via Wikidata · CC0
~4 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- References
Travoprost, sold under the brand name Travatan among others, is a medication used to treat high pressure inside the eye including glaucoma. Specifically it is used for open angle glaucoma when other agents are not sufficient. It is used as an eye drop. Effects generally occur within two hours.
Common side effects include red eyes, blurry vision, eye pain, dry eyes, and change in color of the eyes. Other significant side effects may include cataracts. Use during pregnancy or breastfeeding is generally not recommended. It is a prostaglandin analog and works by increasing the outflow of aqueous fluid from the eyes.
Excerpted from Wikipedia’s “travoprost” article, available under the CC BY-SA 4.0 licence.