phenprocoumon
Sign in to saveAlso known as Liquamar, 3-(1'-Phenyl-propyl)-4-oxycoumarin, Fenprocumon, 3-(alpha-Phenylpropyl)-4-hydroxycoumarin, Fenprocumone, Phenprocoumonum, Phenprocoumone, 4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one
Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting anticoagulant to be taken by mouth, and a coumarin derivative. It acts as a vitamin K antagonist and inhibits blood clotting (coagulation) by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders such as heart attacks and pulmonary (lung) embolism. The most common adverse effect is bleeding. The drug interacts with a large number of other medications, including aspirin and St John's Wort. It is the standard coumarin us
Research
1,398 papers- Phenprocoumon poisonings.Legal medicine (Tokyo, Japan) · 2009
- Carbamazepine-phenprocoumon interaction.European neurology · 1997
- Ginger-associated overanticoagulation by phenprocoumon.The Annals of pharmacotherapy · 2004
- [Phenprocoumon-induced necrotizing hepatitis].Deutsche medizinische Wochenschrift (1946) · 2001
- Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol.Clinical pharmacokinetics · 2005
via PubMed
Wikidata facts
- Mass
- 280.109944
Show 4 more facts
- chemical formula
- C₁₈H₁₆O₃
- canonical SMILES
- CCC(C=1C(=O)OC2=C(C1O)C=CC=C2)C3=CC=CC=C3
- defined daily dose
- 3
- Commons category
- Phenprocoumon
Sources (7)
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Article
18 sectionsContents
- Medical uses
- Dosing
- Contraindications
- Adverse effects
- Overdose
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Pharmacogenomics
- Chemistry
- Comparison with other anticoagulants
- Warfarin
- Direct factor Xa inhibitors
- Low-molecular-weight heparins
- History
- References
- External links
Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting anticoagulant to be taken by mouth, and a coumarin derivative. It acts as a vitamin K antagonist and inhibits blood clotting (coagulation) by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders such as heart attacks and pulmonary (lung) embolism. The most common adverse effect is bleeding. The drug interacts with a large number of other medications, including aspirin and St John's Wort. It is the standard coumarin used in Germany, Austria, and other European countries.
==Medical uses==
Gallery (2)
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