edoxaban
Also known as DU-176, DU-176b
Edoxaban, sold under the brand name Lixiana among others, is an anticoagulant medication and a direct factor Xa inhibitor. It is taken by mouth.
Chemical data
- Formula
- C24H30ClN7O4S
- Molecular weight
- 548.1 g/mol
- IUPAC name
- N'-(5-chloro-2-pyridinyl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide
- SMILES
- CN1CCC2=C(C1)SC(=N2)C(=O)N[C@@H]3C[C@H](CC[C@@H]3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C
- InChIKey
- HGVDHZBSSITLCT-JLJPHGGASA-N
- XLogP
- 1.4
- Polar surface area
- 165 Ų
- H-bond donors
- 3
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Research
2,849 papers~6 min read
Article
9 sectionsContents
- Medical uses
- Contraindications and notes
- Adverse effects
- Overdose
- Mechanism of action
- Pharmacokinetics
- Comparison to other anticoagulants
- Generic availability
- References
Edoxaban, sold under the brand name Lixiana among others, is an anticoagulant medication and a direct factor Xa inhibitor. It is taken by mouth.
Compared with warfarin, it has fewer drug interactions, and does not require regular assessment of blood samples for prothrombin time to assure safe anticoagulant therapy.