plasmin
Sign in to saveAlso known as PLG
Plasmin is an important enzyme () present in blood that degrades many blood plasma proteins, including fibrin clots. The degradation of fibrin is termed fibrinolysis. In humans, the plasmin protein (in the zymogen form of plasminogen) is encoded by the PLG gene.
Protein · UniProt
Plasminogen
- Gene
- PLG
- Organism
- Homo sapiens (Human)
- Length
- 810 aa
- Molecular mass
- 90,569 Da
- Evidence
- 1: Evidence at protein level
Protease which primary function is to degrade fibrin, the main component of blood clots (PubMed:6094526, PubMed:6919539). Also cleaves other components of blood clots like thrombospondin-1/THBS1 and von Willebrand factor/VWF (PubMed:24449821, PubMed:7679575). Can also directly and/or through the activation of other proteases degrade the various components of the extracellular matrix including collagen, fibronectin and laminin (PubMed:14699093, PubMed:28849762, PubMed:9171346). Thereby, regulates a variety of biological processes including embryonic development, tissue remodeling, and inflam…
Swiss-Prot (reviewed) · via UniProt
Research
16,495 papers- Assessing Plasmin Generation in Health and Disease.International journal of molecular sciences · 2021
- Plasmin: A Modulator of Immune Function.Seminars in thrombosis and hemostasis · 2017
- Plasmin as a proinflammatory cell activator.Journal of leukocyte biology · 2012
- Plasmin in Parasitic Chronic Infections: Friend or Foe?Trends in parasitology · 2016
- Plasmin-dependent modulation of the blood-brain barrier: a major consideration during tPA-induced thrombolysis?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014
via PubMed
Clinical Trials
23 registered- UNKNOWNTF, TFPI and Plasmin as Novel Bio-markers in Early Diagnosis of Lupus NephritisAssiut University · NCT04218890
- PHASE2UNKNOWNAnfibatide Treatment in STEMI PatientsLee's Pharmaceutical Limited · NCT02495012
- PHASE2COMPLETEDA Study of Intra-thrombus Plasmin (Human) In Acute Peripheral Arterial OcclusionGrifols Therapeutics LLC · NCT01222117
- PHASE2TERMINATEDStudy to Evaluate Plasmin for the Creation of a Posterior Vitreous DetachmentBausch & Lomb Incorporated · NCT00348439
- PHASE1TERMINATEDPhase I Study of Aprotinin in Advanced Breast CancerDartmouth-Hitchcock Medical Center · NCT00354900
- PHASE4COMPLETEDTranexamic Acid to Reduce Blood Loss in Hemorrhagic Caesarean DeliveryUniversity Hospital, Lille · NCT02797119
~6 min read
Article
8 sectionsContents
- Function
- Mechanism of plasminogen activation
- Mechanism of plasmin inactivation
- Pathology
- Interactions
- References
- Further reading
- External links
Plasmin is an important enzyme () present in blood that degrades many blood plasma proteins, including fibrin clots. The degradation of fibrin is termed fibrinolysis. In humans, the plasmin protein (in the zymogen form of plasminogen) is encoded by the PLG gene.
== Function ==