GP6

Name

glycoprotein VI platelet

Type

protein-coding

Position

55,013,705–55,038,264 (−)

Aliases

BDPLT11, GPIV, GPVI

Ensembl

ENSG00000276065

RefSeq RNA

NM_001083899.2, NM_001256017.2, NM_016363.5, XM_054321150.1, XM_054321151.1

RefSeq protein

NP_001077368.2, NP_001242946.2, NP_057447.5, XP_054177125.1, XP_054177126.1

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].