coagulation factor IX
Sign in to saveAlso known as PTC, plasma thromboplastic component, factor 9, factor IX F9, Christmas factor, F9, plasma thromboplastin component
mammalian protein found in Homo sapiens
In the Vinony graph
Within Vinony's link graph, coagulation factor IX is referenced by 425 other articles, and connects out to blood coagulation, Coagulation factor II, thrombin and Q180686.
It is catalogued under topics including Chemical articles without CAS registry number, Chemical pages without ChemSpiderID and Chemical pages without DrugBank identifier.
Its subject is documented across 25 Wikipedia language editions.
Protein · UniProt
Coagulation factor IX
- Gene
- F9
- Organism
- Homo sapiens (Human)
- Length
- 461 aa
- Molecular mass
- 51,778 Da
- Evidence
- 1: Evidence at protein level
Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa (PubMed:8295821, PubMed:2592373, PubMed:20121197, PubMed:20121198, PubMed:1730085, PubMed:19846852, PubMed:39880037)
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
273 registered- COMPLETEDAre There Differences Between Carriers of Haemophilia A and B?Cliniques universitaires Saint-Luc- Université Catholique de Louvain · NCT05217992
- PHASE1COMPLETEDStudy of FVIIa Variant BAY86-6150 (B0189) in Subjects With Moderate or Severe Hemophilia Types A or B With or Without InhibitorsBayer · NCT01921855
- COMPLETEDStudy of Prophylaxis, ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated With ADVATE or RIXUBISBaxalta now part of Shire · NCT02190149
- PHASE1/PHASE2COMPLETEDTrial of AAV5-hFIX in Severe or Moderately Severe Hemophilia BCSL Behring · NCT02396342
- NACOMPLETEDGene Therapy for Chinese Hemophilia BInstitute of Hematology & Blood Diseases Hospital, China · NCT04135300
- PHASE1COMPLETEDSafety and Mode of Action of a Single Dose and Multiple Doses of Long Acting Activated Recombinant Human Factor VII in Patients With Haemophilia A and BNovo Nordisk A/S · NCT00922792