Structure via PubChem · Public domain (PubChem)
fostamatinib
Sign in to saveAlso known as R 788, R-788, R7935788, tamatinib fosdium
Fostamatinib, sold under the brand names Tavalisse and Tavlesse, is a tyrosine kinase inhibitor medication for the treatment of chronic immune thrombocytopenia (ITP). The drug is administered by mouth.
Key facts
- Drug.DailyMedID
- Fostamatinib
- Drug.image
- Fostamatinib.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Tavalisse, Tavlesse
- Drug.MedlinePlus
- a618025
- Drug.licence_EU
- yes
- Drug.pregnancy_category
- Not recommended
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- B02
- Drug.ATC_suffix
- BX09
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.bioavailability
- 55% (tamatinib metabolite)
- Drug.protein_bound
- 98% (tamatinib metabolite)
- Drug.metabolism
- Gut (ALP to tamatinib)Liver (tamatinib metabolite by CYP3A4, UGT1A9)
- Drug.elimination_half life
- 15 hours
via Wikipedia infobox
Chemical data
- Formula
- C23H26FN6O9P
- Molecular weight
- 580.5 g/mol
- IUPAC name
- [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2018
- Admin. routes
- oral
- Indications
- diffuse large B-cell lymphoma, rheumatoid arthritis, IGA glomerulonephritis, lymphoma
via ChEMBL · EBI
~15 min read
Encyclopedic overview
12 sectionsContents
- Medical uses
- Pharmacology
- Mechanism of action
- Clinical trials
- Rheumatoid arthritis
- Autoimmune thrombocytopenia
- Autoimmune hemolytic anemia
- Immunoglobulin A nephropathy
- History
- Synthesis
- References
- External links
{{Infobox drug | drug_name = | INN = | type = | image = Fostamatinib.svg | image_class = skin-invert-image | width = | alt = | caption =
| pronounce = | tradename = Tavalisse, Tavlesse | Drugs.com = | MedlinePlus = a618025 | licence_CA = | licence_EU = yes | DailyMedID = Fostamatinib | licence_US = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category = Not recommended | routes_of_administration = By mouth | class = | ATCvet = | ATC_prefix = B02 | ATC_suffix = BX09 | ATC_supplemental =
Excerpted from Wikipedia’s “fostamatinib” article, available under the CC BY-SA 4.0 licence.