Coagulation factor II, thrombin
Sign in to saveAlso known as serine protease, prothrombin, F2, prothrombin B-chain, Coagulation factor II, thrombin, prepro-coagulation factor II, thrombin factor II
thumb|360px|alt=Schematic diagram of the blood coagulation and protein C pathways. In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa V to Va, fibrinogen to fibrin. In addition, thrombin promotes platelet activation and aggregation via activation of protease-activated receptors on the cell membrane of the platelet. Thrombin also cross over into the protein C pathway by converting protein C into APC. APC in turn converts factor V into Vi, and VIIIa into VIIIi. Finally APC activates PAR-1 and EPCR.|Role of thrombin in the blood coagulation cascade
Protein · UniProt
Prothrombin
- Gene
- F2
- Organism
- Homo sapiens (Human)
- Length
- 622 aa
- Molecular mass
- 70,037 Da
- Evidence
- 1: Evidence at protein level
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (PubMed:2019570, PubMed:21976677). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (PubMed:30568593, PubMed:9780208)
Swiss-Prot (reviewed) · via UniProt
Research
8,902 papers- Pathogenic antibodies to coagulation factors. Part II. Fibrinogen, prothrombin, thrombin, factor V, factor XI, factor XII, factor XIII, the protein C system and von Willebrand factor.Journal of thrombosis and haemostasis : JTH · 2005
- The role of thrombin exosites I and II in the activation of human coagulation factor V.The Journal of biological chemistry · 2007
- Thrombin generation and coagulation factor activities: evaluation and comparison with the international normalized ratio.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 2009
- Congenital prothrombin deficiency.Seminars in thrombosis and hemostasis · 2009
- Actions of thrombin in the interstitium.Journal of thrombosis and haemostasis : JTH · 2016
via PubMed
Clinical Trials
54 registered- PHASE2COMPLETEDAnti-thrombin III (ATIII) vs Placebo in Children (<7mo) Undergoing Open Congenital Cardiac SurgeryDuke University · NCT02103114
- PHASE1/PHASE2COMPLETEDA Study Evaluating the Safety and Preliminary Efficacy of sFilm-FS in Controlling Parenchymal Bleeding During Elective Hepatic SurgerySealantium Medical Ltd. · NCT04660721
- UNKNOWNTFPI Levels in Haemophilia A and B PatientsCHU de Reims · NCT04570696
- PHASE3RECRUITINGStudy of the Long-term Effects of P2Y12 Inhibitor Monotherapy and Coagulation Markers After Percutaneous Coronary Angioplasty.Cardiocentro Ticino · NCT07582835
- PHASE4COMPLETEDTreatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran EtexilateBoehringer Ingelheim · NCT01184989
- PHASE2COMPLETEDStudy of PER977 Administered to Subjects With Steady State Edoxaban Dosing and Re-anticoagulation With EdoxabanPerosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc. · NCT02207257
Wikidata facts
Show 2 more facts
- Commons category
- Thrombin
- exact match
- purl.uniprot.org/uniprot/P00734
Sources (8)
via Wikidata · CC0
~11 min read
Article
16 sectionsContents
- History
- Physiology
- Synthesis
- Mechanism of action
- Negative feedback
- Structure
- Gene
- Role in disease
- Applications
- Research tool
- Medicine and surgery
- Food production
- See also
- References
- Further reading
- External links
thumb|360px|alt=Schematic diagram of the blood coagulation and protein C pathways. In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa V to Va, fibrinogen to fibrin. In addition, thrombin promotes platelet activation and aggregation via activation of protease-activated receptors on the cell membrane of the platelet. Thrombin also cross over into the protein C pathway by converting protein C into APC. APC in turn converts factor V into Vi, and VIIIa into VIIIi. Finally APC activates PAR-1 and EPCR.|Role of thrombin in the blood coagulation cascade
Thrombin (factor IIa, ) is a serine protease that converts fibrinogen into strands of insoluble fibrin, as well as catalyzing many other coagulation-related reactions.