coagulation factor VII

Protein · UniProt

Coagulation factor VII

Gene

F7

Organism

Homo sapiens (Human)

Length

466 aa

Molecular mass

51,594 Da

Evidence

1: Evidence at protein level

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium (PubMed:271951)

• COMPLETED
  Recombinant Activated Factor VII in the Management of Massive Bleeding in Hospital Universiti Sains MalaysiaUniversiti Sains Malaysia · NCT03251547
• PHASE1COMPLETED
  Safety and Mode of Action of a Single Dose and Multiple Doses of Long Acting Activated Recombinant Human Factor VII in Patients With Haemophilia A and BNovo Nordisk A/S · NCT00922792
• PHASE2COMPLETED
  Safety and Efficacy of 3 Different Doses of Long Acting Factor VII in Haemophilia A or B Patients With InhibitorsNovo Nordisk A/S · NCT00951405
• COMPLETED
  Observational Study on the Efficacy and Safety of NovoSeven® During "Real-life" Usage in GermanyNovo Nordisk A/S · NCT00697320
• PHASE3COMPLETED
  Recombinant Factor VIIa in Acute Intracerebral HaemorrhageNovo Nordisk A/S · NCT00127283
• PHASE2COMPLETED
  Safety and Preliminary Efficacy of Recombinant Activated Factor VII in Subjects With Traumatic Brain InjuryNovo Nordisk A/S · NCT00123591

via ClinicalTrials.gov

Wikidata facts

via Wikidata · CC0