Protein S
Sign in to saveAlso known as vitamin K-dependent plasma protein S, PROS1, protein Sa, vitamin K-dependent protein S, protein S (alpha)
mammalian protein found in Homo sapiens
Protein · UniProt
Vitamin K-dependent protein S
- Gene
- PROS1
- Organism
- Homo sapiens (Human)
- Length
- 676 aa
- Molecular mass
- 75,123 Da
- Evidence
- 1: Evidence at protein level
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis
3D-structureBlood coagulationCalciumCleavage on pair of basic residuesDisease variantDisulfide bondEGF-like domainFibrinolysis
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Swiss-Prot (reviewed) · via UniProt
Clinical Trials
101 registered- PHASE1TERMINATEDIntentional Rejection of the Donor Graft Using Recipient Leukocyte Infusion(s) Following Nonmyeloablative Allogeneic Stem Cell TransplantMassachusetts General Hospital · NCT00909948
- PHASE1WITHDRAWNEvaluating the Safety and Immunogenicity of the IHV01 Protein Vaccine Primed and Co-Administered With HIV DNA CON-S Env Vaccine in Healthy, HIV-1-Uninfected AdultsNational Institute of Allergy and Infectious Diseases (NIAID) · NCT03505060
- RECRUITINGVR Pupillometry in Cognitive ImpairmentMax-Planck-Institute of Psychiatry · NCT07402356
- PHASE1COMPLETEDStudy to Assess the Effect of Food and Acid Reducing Agents on the Absorption of Capivasertib in Healthy ParticipantsAstraZeneca · NCT04944771
- PHASE2COMPLETEDWT1 Vaccine Treatment of Patients in Remission From Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL)Sellas Life Sciences Group · NCT01266083
- PHASE2COMPLETEDA Pilot Phase 2 Trial of the Immunogenicity, and Safety of GI-4000; an Inactivated Recombinant S. Cerevisiae Expressing Mutant Ras Protein, as Consolidation Therapy Following Curative Treatment for Stage I-III Non-Small Cell Lung Cancer (NSCLC) With Tumor Sequence Confirmation of K-ras MutationGlobeImmune · NCT00655161