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GeneQ17910930· pop 6· linked from 86 articles

CSPG4

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Also known as HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2, chondroitin sulfate proteoglycan 4, CSPG4A

Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.

Gene data

CSPG4
Name
chondroitin sulfate proteoglycan 4
Type
protein-coding
Position
75,674,322–75,712,856 (−)
Aliases
CSPG4A, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
Ensembl
ENSG00000173546
RefSeq RNA
NM_001897.5, XM_047432196.1, XM_054377370.1
RefSeq protein
NP_001888.2, XP_047288152.1, XP_054233345.1

A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

Developmental BiologyMetabolismGlycosaminoglycan metabolismDiseaseChondroitin sulfate/dermatan sulfate metabolismGlycosaminoglycan-protein linkage region biosynthesisCS-GAG biosynthesisDS-GAG biosynthesisCS/DS degradationDiseases associated with glycosaminoglycan metabolism

via MyGene.info

Gene · Ensembl

chondroitin sulfate proteoglycan 4

Symbol
CSPG4
Biotype
Protein coding
Organism
Homo sapiens
Location
15:75,674,322-75,712,856
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~2 min read

Encyclopedic overview

6 sections
Contents
  • Function
  • Implications in disease
  • See also
  • References
  • Further reading
  • External links

Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.

== Function == CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human melanoma cells.

Excerpted from Wikipedia’s “CSPG4” article, available under the CC BY-SA 4.0 licence.

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