Platelet factor 4

Protein · UniProt

Platelet factor 4

Gene

PF4

Organism

Homo sapiens (Human)

Length

101 aa

Molecular mass

10,845 Da

Evidence

1: Evidence at protein level

Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation (PubMed:29930254, PubMed:9531587). Acts via different functional receptors including CCR1, CXCR3A or CXCR3B (PubMed:18174362, PubMed:29930254). Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling (PubMed:18174362, PubMed:24469069). Neutralizes the anticoagulant effect of heparin by binding more strongly to he…

• PHASE1/PHASE2UNKNOWN
  Stem Cell Therapy and Growth Factor Ovarian in Vitro ActivationForever Young d.o.o. · NCT04009473
• NATERMINATED
  Evaluation of Anti-platelet Factor 4/Heparin Antibodies in Hemodialysis PatientsW.L.Gore & Associates · NCT02165761
• RECRUITING
  Study Regarding the Incidence of Anti-platelet Factor 4-antibodies in Patients Aged 18 to 60 Years With Spontaneous or Infection- or Vaccine-associated or Recurrent Venous and/or Arterial ThrombosisCardioangiologisches Centrum Bethanien · NCT06650826
• PHASE2COMPLETED
  Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)Merck Sharp & Dohme LLC · NCT03797326
• COMPLETED
  Level of Expression and Prognostic Value of CXCL4, CXCL4L1 and CXCR3 in Renal Cell CarcinomaUniversity Hospital, Bordeaux · NCT01339975
• NANOT_YET_RECRUITING
  Comparison of Citrate and Heparin Anticoagulation During Postdilution HemodiafiltrationUniversity Medical Centre Ljubljana · NCT07618858

via ClinicalTrials.gov

Wikidata facts

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