CX3CL1

Name

C-X3-C motif chemokine ligand 1

Type

protein-coding

Position

57,372,457–57,385,044 (+)

Aliases

ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin

Ensembl

ENSG00000006210

RefSeq RNA

NM_001304392.3, NM_002996.6

RefSeq protein

NP_001291321.1, NP_002987.1

This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif chemokine receptor 1 gene product. This gene plays a role in a wide range of diseases, including cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections. [provided by RefSeq, Sep 2017].

via MyGene.info

Gene · Ensembl

C-X3-C motif chemokine ligand 1

Symbol

CX3CL1

Biotype

Protein coding

Organism

Homo sapiens

Location

16:57,372,457-57,385,044

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein CX3CL1 PDB 1b2t.png

via Wikidata · CC0