Pro-platelet basic protein

Also known as neutrophil-activating peptide 2, CXC chemokine ligand 7, MDGF, leukocyte-derived growth factor, small inducible cytokine B7, C-X-C motif chemokine 7, platelet basic protein, thrombocidin 1

Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene.

Protein · UniProt

Platelet basic protein

Gene: PPBP
Organism: Homo sapiens (Human)
Length: 128 aa
Molecular mass: 13,894 Da
Evidence: 1: Evidence at protein level

LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitiz…

3D-structureAntibioticAntimicrobialChemotaxisCleavage on pair of basic residuesCytokineDirect protein sequencingDisulfide bond

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Swiss-Prot (reviewed) · via UniProt

Clinical Trials

7 registered

PHASE2COMPLETED
RAPA-201 T Cell Therapy for Relapsed, Refractory Multiple MyelomaRapa Therapeutics LLC · NCT04176380
PHASE1/PHASE2TERMINATED
Th1/Tc1 Immunotherapy Following Stem Cell Transplantation in Multiple MyelomaNational Cancer Institute (NCI) · NCT01239368
PHASE1/PHASE2RECRUITING
RAPA-201 Therapy of Solid TumorsRapa Therapeutics LLC · NCT05144698
PHASE1COMPLETED
Stem Cell Transplant With Th2/Tc2 Cells to Treat Advanced Breast CancerNational Cancer Institute (NCI) · NCT00079625
PHASE2NOT_YET_RECRUITING
Phase 2b of RAPA-201 Cell Therapy in Post-PD-(L)-1 MelanomaRapa Therapeutics LLC · NCT06708455
NACOMPLETED
Sunitinib Malate in Treating Patients With Kidney CancerCentre Antoine Lacassagne · NCT00943839

via ClinicalTrials.gov

Wikidata facts

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exact match: purl.uniprot.org/uniprot/P02775

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Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene.

The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP).