interleukin 10

Protein · UniProt

Interleukin-10

Gene

IL10

Organism

Homo sapiens (Human)

Length

178 aa

Molecular mass

20,517 Da

Evidence

1: Evidence at protein level

Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammato…

• PHASE1COMPLETED
  Phase I Trial of Recombinant Human Interleukin-10 (SCH 52000) in Patients With Wegener's GranulomatosisNational Institute of Allergy and Infectious Diseases (NIAID) · NCT00001761
• PHASE4COMPLETED
  Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?Shahid Beheshti University of Medical Sciences · NCT04323852
• PHASE2COMPLETED
  HAT in Eye Complications of Behcet's DiseaseNational Eye Institute (NEI) · NCT00001865
• NAUNKNOWN
  Lactobacillus Reuteri Versus Placebo in the Treatment and Prevention of Infantile ColicAzienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna · NCT00893711
• PHASE1/PHASE2UNKNOWN
  Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe NeutropeniaNational Research Center for Hematology, Russia · NCT01849237
• NACOMPLETED
  Aerobic Exercise vs Physiological Ischemic Training in Stage 2 HypertensionUniversitas Padjadjaran · NCT07375407

via ClinicalTrials.gov

Wikidata facts

via Wikidata · CC0