sepsis

Also known as septicemia, blood poisoning, blood-poisoning

Sepsis is a potentially life-threatening condition that arises when the body's dysregulated response to infection causes injury to its own tissues and organs.

AI overview

Sepsis is a serious medical emergency that occurs when the body's immune system overreacts to an infection and starts damaging its own tissues and organs instead of just fighting off germs. It matters because this condition can quickly become life-threatening if not treated promptly.

AI-generated from the Wikipedia summary — may contain errors.

Key facts

Medical condition (new).prognosis: Mortality: sepsis ~30%, severe sepsis ~50%, septic shock ~80%. The mortality may be lower if treated aggressively and early, depending on the organism and disease, the patient's previous health, and the abilities of the treatment location and its staff.
Medical condition (new).frequency: In 2017, there were 48.9 million cases and 11 million sepsis-related deaths worldwide (according to WHO)
Medical condition (new).name: Sepsis
Medical condition (new).image: sepsis-Mikrothomben1.JPG
Medical condition (new).caption: Skin blotching and inflammation caused by sepsis
Medical condition (new).field: infectious disease, critical care medicine, emergency medicine
Medical condition (new).onset: May be rapid (less than three hours) or prolonged (several days)
Medical condition (new).causes: Immune response triggered by an infection
Medical condition (new).diagnosis: Systemic inflammatory response syndrome (SIRS), qSOFA
Medical condition (new).prevention: Influenza vaccination, vaccines, pneumonia vaccination
Medical condition (new).treatment: Intravenous fluids, antimicrobials, vasopressors, blood filtration or dialysis

via Wikipedia infobox

Research

246,254 papers

Epidemiology of sepsis and septic shock.ReviewCurrent opinion in anaesthesiology · 2021Chiu C, Legrand MDOI: 10.1097/ACO.0000000000000958
Biomarkers of sepsis.ReviewCritical reviews in clinical laboratory sciences · 2013Faix JDDOI: 10.3109/10408363.2013.764490
Potential biomarker for diagnosis and therapy of sepsis: Lactylation.ReviewImmunity, inflammation and disease · 2023Sun Z, Song Y, Li J et al.DOI: 10.1002/iid3.1042
Recognition and management of sepsis: the nurse's role.British journal of nursing (Mark Allen Publishing) · 2020Bleakley G, Cole MDOI: 10.12968/bjon.2020.29.21.1248
Sepsis in Older Adults.ReviewInfectious disease clinics of North America · 2017Rowe TA, McKoy JMDOI: 10.1016/j.idc.2017.07.010
Sepsis phenotypes, subphenotypes, and endotypes: are they ready for bedside care?ReviewCurrent opinion in critical care · 2024Scherger SJ, Kalil ACDOI: 10.1097/MCC.0000000000001178
Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment.ReviewOxidative medicine and cellular longevity · 2022Pan S, Lv Z, Wang R et al.DOI: 10.1155/2022/1328729
Sepsis, a 2020 review for the internist.ReviewRomanian journal of internal medicine = Revue roumaine de medecine interne · 2020Purcarea A, Sovaila SDOI: 10.2478/rjim-2020-0012

via PubMed

Wikidata facts

Image: Sepsis-Mikrothomben3.JPG

Show 5 more facts

Commons category: Sepsis
ICPC 2 ID: A78
exact match: purl.obolibrary.org/obo/SYMP_0019148
WordLift URL: data.medicalrecords.com/medicalrecords/healthwise/sepsis
P8168: Aelius Moeris

Sources (10)

via Wikidata · CC0

~54 min read

Article

33 sections

Contents

Signs and symptoms
Cause
Pathophysiology
Microbial factors
Host factors
Diagnosis
Definitions
End-organ dysfunction
Biomarkers
Differential diagnosis
Neonatal sepsis
Treatment
Antibiotics
Intravenous fluids
Blood products
Vasopressors
Steroids
Anesthesia
Source control
Early goal-directed therapy
Newborns
Other
Prognosis
Epidemiology
History
Society and culture
Economics
Education
Awareness
Research
See also
References
External links

Sepsis is a potentially life-threatening condition that arises when the body's dysregulated response to infection causes injury to its own tissues and organs.

This initial stage of sepsis is followed by dysregulation of the immune system. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion. There may also be symptoms related to a specific infection, such as a cough with pneumonia, or painful urination with a kidney infection. The very young, old, and people with a weakened immune system may not have any symptoms specific to their infection, and their body temperature may be low or normal instead of constituting a fever. Severe sepsis may cause organ dysfunction and significantly reduced blood flow. The presence of low blood pressure, high blood lactate, or low urine output may suggest poor blood flow. Septic shock is low blood pressure due to sepsis that does not improve after fluid replacement or requires medications to raise the blood pressure.