IL5

Name

interleukin 5

Type

protein-coding

Position

132,541,445–132,556,838 (−)

Aliases

EDF, IL-5, TRF

Ensembl

ENSG00000113525

RefSeq RNA

NM_000879.3, XM_005271988.5, XM_011543373.4, XM_047417148.1, XM_054352518.1

RefSeq protein

NP_000870.1, XP_005272045.1, XP_011541675.1, XP_047273104.1, XP_054208493.1

This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013].

via MyGene.info

Gene · Ensembl

interleukin 5

Symbol

IL5

Biotype

Protein coding

Organism

Homo sapiens

Location

5:132,541,444-132,556,838

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

IL5 Crystal Structure.rsh.png

via Wikidata · CC0