File:Blausen_0352_Eosinophil_(crop).png · Wikimedia Commons · See Wikimedia Commons
eosinophil
Sign in to saveAlso known as eosinophil granulocyte, Eozinofil, eosinophils
Eosinophils, sometimes called eosinophiles or, less commonly, acidophils, are a variety of white blood cells and one of the immune system components responsible for combating multicellular parasites and certain infections in vertebrates. Along with mast cells and basophils, they also control mechanisms associated with allergy and asthma. They are granulocytes that develop during hematopoiesis in the bone marrow before migrating into blood, after which they are terminally differentiated and do not multiply.
Eosinophils are a type of white blood cell that helps your immune system fight parasitic infections and also plays a role in allergic reactions and asthma. These cells are produced in your bone marrow, travel through your bloodstream, and then settle into tissues where they perform their specialized functions.
AI-generated from the Wikipedia summary — may contain errors.
Key facts
- Cell.Name
- Eosinophil
- Cell.Image2
- Eosinophil blood smear.JPG
- Cell.Caption2
- Eosinophil under the microscope (400×) from a peripheral blood smear. Red blood cells surround the eosinophil, two platelets at the top left corner.
- Cell.Image
- Blausen 0352 Eosinophil (crop).png
- Cell.Caption
- 3D rendering of eosinophil
- Cell.System
- Immune system
- Cell.Pronunciation
- )
via Wikipedia infobox
Research
93,230 papers- Eosinophil diversity in asthma.Biochemical pharmacology · 2020
- Eosinophil-Related Disease and the Skin.The journal of allergy and clinical immunology. In practice · 2018
- Regulation of eosinophil functions by autophagy.Seminars in immunopathology · 2021
- The Eosinophil in Infection.Clinical reviews in allergy & immunology · 2016
- Human eosinophil-lymphocyte interactions.Memorias do Instituto Oswaldo Cruz · 1997
via PubMed
~12 min read
Encyclopedic overview
11 sectionsContents
- Development
- Function
- Granule proteins
- Clinical significance
- Blood count
- Eosinophilia
- Treatment
- Animal studies
- See also
- References
- External links
Eosinophils, sometimes called eosinophiles or, less commonly, acidophils, are a variety of white blood cells and one of the immune system components responsible for combating multicellular parasites and certain infections in vertebrates. Along with mast cells and basophils, they also control mechanisms associated with allergy and asthma. They are granulocytes that develop during hematopoiesis in the bone marrow before migrating into blood, after which they are terminally differentiated and do not multiply.
These cells are eosinophilic or "acid-loving" due to their large acidophilic cytoplasmic granules, which show their affinity for acids by their affinity to coal tar dyes: Normally transparent, it is this affinity that causes them to appear brick-red after staining with eosin, a red dye, using the Romanowsky method. The staining is concentrated in small granules within the cellular cytoplasm, which contain many chemical mediators, such as eosinophil peroxidase, ribonuclease (RNase), deoxyribonucleases (DNase), lipase, plasminogen, and major basic protein. These mediators are released by a process called degranulation following activation of the eosinophil, and are toxic to both parasite and host tissues.
Excerpted from Wikipedia’s “eosinophil” article, available under the CC BY-SA 4.0 licence.