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basophil
Sign in to saveAlso known as basophils, basophil leukocyte, basophilic granulocyte
Basophils are a type of white blood cell. Basophils are the least common type of granulocyte, representing about 0.5% to 1% of circulating white blood cells. They are the largest type of granulocyte. They are responsible for inflammatory reactions during immune response, as well as in the formation of acute and chronic allergic diseases, including anaphylaxis, asthma, atopic dermatitis and hay fever. They also produce compounds that coordinate immune responses, including histamine and serotonin that induce inflammation, and heparin that prevents blood clotting, although there are less than tha
Key facts
- Cell.Name
- Basophil
- Cell.Image
- Blausen 0077 Basophil (crop).png
- Cell.Caption
- 3D rendering of a basophil
- Cell.Image2
- Базофіли.jpg
- Cell.Caption2
- Dyed basophils among red blood cells with poikilocytosis
- Cell.System
- Immune system
via Wikipedia infobox
Research
21,990 papersvia PubMed
Wikidata facts
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- Basophil.png
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- Commons category
- Basophils
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Article
12 sectionsContents
- Structure
- Function
- CD200
- Secretions
- Clinical significance
- Immunophenotyping
- Allergy diagnosis
- Etymology and pronunciation
- Additional images
- See also
- References
- External links
Basophils are a type of white blood cell. Basophils are the least common type of granulocyte, representing about 0.5% to 1% of circulating white blood cells. They are the largest type of granulocyte. They are responsible for inflammatory reactions during immune response, as well as in the formation of acute and chronic allergic diseases, including anaphylaxis, asthma, atopic dermatitis and hay fever. They also produce compounds that coordinate immune responses, including histamine and serotonin that induce inflammation, and heparin that prevents blood clotting, although there are less than that found in mast cell granules. Mast cells were once thought to be basophils that migrated from the blood into their resident tissues (connective tissue), but they are now known to be different types of cells.
Basophils were discovered in 1879 by German physician Paul Ehrlich, who one year earlier had found a cell type present in tissues that he termed mastzellen (now mast cells). Ehrlich received the 1908 Nobel Prize in Physiology or Medicine for his discoveries.