CYSLTR1

Name

cysteinyl leukotriene receptor 1

Type

protein-coding

Chromosome

X

Position

78,270,496–78,327,845 (−)

Aliases

CYSLT1, CYSLT1R, CYSLTR, HMTMF81

Ensembl

ENSG00000173198

RefSeq RNA

NM_001282186.2, NM_001282187.2, NM_001282188.2, NM_006639.4

RefSeq protein

NP_001269115.1, NP_001269116.1, NP_001269117.1, NP_006630.1

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].

via MyGene.info

Gene · Ensembl

cysteinyl leukotriene receptor 1

Symbol

CYSLTR1

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr X:78,270,496-78,327,845

Strand

Reverse (−)

Assembly

GRCh38