VIPR2

Also known as C16DUPq36.3, DUP7q36.3, PACAP-R-3, PACAP-R3, VIP-R-2, VPAC2, VPAC2R, VPCAP2R

Vasoactive intestinal peptide receptor 2 also known as VPAC2, is a G-protein coupled receptor that in humans is encoded by the VIPR2 gene.

Gene data

VIPR2

Name: vasoactive intestinal peptide receptor 2
Type: protein-coding
Position: 159,028,175–159,144,944 (−)
Aliases: C16DUPq36.3, DUP7q36.3, PACAP-R-3, PACAP-R3, VIP-R-2, VPAC2, VPAC2R, VPCAP2R
Ensembl: ENSG00000106018
RefSeq RNA: NM_001304522.2, NM_001308259.1, NM_003382.5, NR_130758.2
RefSeq protein: NP_001291451.1, NP_001295188.1, NP_003373.2

This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011].

Gene Ontology

Biological process

signal transduction cell surface receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway cell-cell signaling

Molecular function

pituitary adenylate cyclase-activating polypeptide receptor activity transmembrane signaling receptor activity G protein-coupled receptor activity G protein-coupled receptor activity vasoactive intestinal polypeptide receptor activity vasoactive intestinal polypeptide receptor activity vasoactive intestinal polypeptide receptor activity protein binding

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane membrane

Pathways

cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Signal Transduction Signaling by GPCR Class B/2 (Secretin family receptors)GPCR downstream signalling G alpha (s) signalling events Glucagon-type ligand receptors GPCR ligand binding GPCRs, Class B Secretin-like

via MyGene.info

Gene · Ensembl

vasoactive intestinal peptide receptor 2

Symbol: VIPR2
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:159,027,660-159,144,991
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 2540
exact match: identifiers.org/ncbigene/7434
genomic end: 159144867
genomic start: 158820866
cytogenetic location: 7q36.3

Sources (6)

via Wikidata · CC0

~2 min read

Article

7 sections

Contents

Tissue distribution
Function
Clinical significance
See also
References
Further reading
External links

Vasoactive intestinal peptide receptor 2 also known as VPAC2, is a G-protein coupled receptor that in humans is encoded by the VIPR2 gene.

== Tissue distribution == VIPR2 is expressed in the uterus, prostate, smooth muscle of the gastrointestinal tract, seminal vesicles and skin, blood vessels and thymus. VIPR2 is also expressed in the cerebellum.