ADRA1B

Name

adrenoceptor alpha 1B

Type

protein-coding

Position

159,865,080–159,973,012 (+)

Aliases

ADRA1, ALPHA1BAR

Ensembl

ENSG00000170214

RefSeq RNA

NM_000679.4, XM_005265818.4, XM_005265819.3, XM_006714821.4, XM_011534435.2

RefSeq protein

NP_000670.1, XP_005265875.1, XP_005265876.1, XP_006714884.1, XP_011532737.1

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

adrenoceptor alpha 1B

Symbol

ADRA1B

Biotype

Protein coding

Organism

Homo sapiens

Location

5:159,865,080-159,973,012

Strand

Forward (+)

Assembly

GRCh38