FZD6

Also known as FZ-6, FZ6, HFZ6, NDNC10, frizzled class receptor 6, NDNC1

Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.

Gene data

FZD6

Name: frizzled class receptor 6
Type: protein-coding
Position: 103,298,433–103,332,866 (+)
Aliases: FZ-6, FZ6, HFZ6, NDNC1, NDNC10
Ensembl: ENSG00000164930
RefSeq RNA: NM_001164615.2, NM_001164616.2, NM_001317796.2, NM_003506.4, NR_133921.2
RefSeq protein: NP_001158087.1, NP_001158088.1, NP_001304725.1, NP_003497.2

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011].

Gene Ontology

Biological process

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Article

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Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. Fz-6 is believed to be the receptor for the WNT4 ligand.