FZD6
Sign in to saveAlso known as FZ-6, FZ6, HFZ6, NDNC10, frizzled class receptor 6, NDNC1
Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.
Gene data
FZD6- Name
- frizzled class receptor 6
- Type
- protein-coding
- Position
- 103,298,433–103,332,866 (+)
- Aliases
- FZ-6, FZ6, HFZ6, NDNC1, NDNC10
- Ensembl
- ENSG00000164930
- RefSeq RNA
- NM_001164615.2, NM_001164616.2, NM_001317796.2, NM_003506.4, NR_133921.2
- RefSeq protein
- NP_001158087.1, NP_001158088.1, NP_001304725.1, NP_003497.2
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
frizzled class receptor 6
- Symbol
- FZD6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:103,298,433-103,332,866
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 2617
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8323
- genomic end
- 104345094
- genomic start
- 104310661
- chromosome
- human chromosome 8
- cytogenetic location
- 8q22.3
- expressed in
- hair follicle
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. Fz-6 is believed to be the receptor for the WNT4 ligand.
Excerpted from Wikipedia’s “FZD6” article, available under the CC BY-SA 4.0 licence.