FUT8
Sign in to saveAlso known as fucosyltransferase 8, CDGF, CDGF1
Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.
In the Vinony graph
Within Vinony's link graph, FUT8 is referenced by 415 other articles, and connects out to glucuronosyltransferase, PubMed and human chromosome 14.
It is catalogued under the topic Genes on human chromosome 14.
Its subject is documented across 5 Wikipedia language editions.
Gene data
FUT8- Name
- fucosyltransferase 8
- Type
- protein-coding
- Position
- 65,285,127–65,747,182 (+)
- Aliases
- CDGF, CDGF1
- Ensembl
- ENSG00000033170
- RefSeq RNA
- NM_001371533.1, NM_001371534.1, NM_001371536.1, NM_004480.4, NM_178154.1
- RefSeq protein
- NP_001358462.1, NP_001358463.1, NP_001358465.1, NP_004471.4, NP_835368.1
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
fucosyltransferase 8
- Symbol
- FUT8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:65,285,127-65,747,182
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein FUT8 PDB 2de0.png
Show 8 more facts
- HomoloGene ID
- 9650
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2530
- genomic end
- 66210839
- genomic start
- 65877310
- chromosome
- human chromosome 14
- cytogenetic location
- 14q23.3
- expressed in
- Achilles tendon
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.
This enzyme belongs to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition to existing oligosaccharides or the four Protein O-fucosyltransferases (POFUTs) that transfer fucose in alpha1-O linkage directly to serines or threonines in specific protein motifs. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternatively spliced variants encoding different isoforms have been identified.
Excerpted from Wikipedia’s “FUT8” article, available under the CC BY-SA 4.0 licence.