NUDT2
Sign in to saveAlso known as APAH1, nudix hydrolase 2, IDDPN
'''Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]' is an enzyme that in humans is encoded by the NUDT2'' gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to NUDT2, and connects out to PubMed, human chromosome 9 and Ensembl genome database project.
It is catalogued under topics including Genes on human chromosome 9 and Nudix hydrolases.
Vinony links it to 5 Wikipedia language editions.
Gene data
NUDT2- Name
- nudix hydrolase 2
- Type
- protein-coding
- Position
- 34,329,496–34,343,713 (+)
- Aliases
- APAH1, IDDPN
- Ensembl
- ENSG00000164978
- RefSeq RNA
- NM_001161.5, NM_001244390.2, NM_147172.3, NM_147173.3
- RefSeq protein
- NP_001152.1, NP_001231319.1, NP_671701.1, NP_671702.1
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
nudix hydrolase 2
- Symbol
- NUDT2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:34,329,496-34,343,713
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein NUDT2 PDB 1xsa.png
Show 7 more facts
- HomoloGene ID
- 896
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/318
- genomic end
- 34343711
- genomic start
- 34329504
- chromosome
- human chromosome 9
- cytogenetic location
- 9p13.3
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
'''Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]' is an enzyme that in humans is encoded by the NUDT2'' gene.
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three transcript variants, all encoding the same protein, have been identified.
Excerpted from Wikipedia’s “NUDT2” article, available under the CC BY-SA 4.0 licence.