NCOA4
Sign in to saveAlso known as ARA70, ELE1, PTC3, RFG, nuclear receptor coactivator 4
Nuclear receptor coactivator 4, also known as Androgen Receptor Activator (ARA70), is a protein that in humans is encoded by the NCOA4 gene. It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.
In the Vinony graph
Vinony's link graph records 51 inbound references to NCOA4, and connects out to PubMed, Ensembl genome database project and protein.
It sits within the topics Gene expression, Genes on human chromosome 10 and Transcription coregulators.
Vinony links it to 4 Wikipedia language editions.
Gene data
NCOA4- Name
- nuclear receptor coactivator 4
- Type
- protein-coding
- Position
- 46,004,867–46,030,670 (−)
- Aliases
- ARA70, ELE1, PTC3, RFG
- Ensembl
- ENSG00000266412
- RefSeq RNA
- NM_001145260.2, NM_001145261.2, NM_001145262.2, NM_001145263.2, NM_005437.4
- RefSeq protein
- NP_001138732.1, NP_001138733.1, NP_001138734.1, NP_001138735.1, NP_005428.1
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
nuclear receptor coactivator 4
- Symbol
- NCOA4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:46,004,867-46,030,670
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 38052
- genomic end
- 51590734
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8031
- chromosome
- human chromosome 10
- genomic start
- 51565108
- cytogenetic location
- 10q11.22
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Interactions
- See also
- References
- Further reading
- External links
Nuclear receptor coactivator 4, also known as Androgen Receptor Activator (ARA70), is a protein that in humans is encoded by the NCOA4 gene. It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.
== Interactions ==
Excerpted from Wikipedia’s “NCOA4” article, available under the CC BY-SA 4.0 licence.