NCOA4
Sign in to saveAlso known as ARA70, ELE1, PTC3, RFG, nuclear receptor coactivator 4
Nuclear receptor coactivator 4, also known as Androgen Receptor Activator (ARA70), is a protein that in humans is encoded by the NCOA4 gene. It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.
Gene data
NCOA4- Name
- nuclear receptor coactivator 4
- Type
- protein-coding
- Aliases
- ARA70, ELE1, PTC3, RFG
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009].
via MyGene.info
Gene · Ensembl
nuclear receptor coactivator 4
- Symbol
- NCOA4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:46,004,867-46,030,670
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 38052
- genomic end
- 51590734
- exact match
- identifiers.org/ncbigene/8031
- genomic start
- 51565108
- cytogenetic location
- 10q11.22
Sources (3)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Interactions
- See also
- References
- Further reading
- External links
Nuclear receptor coactivator 4, also known as Androgen Receptor Activator (ARA70), is a protein that in humans is encoded by the NCOA4 gene. It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.
== Interactions ==