TRIM28

Also known as KAP1, PPP1R157, RNF96, TF1B, TIF1B, tripartite motif containing 28, TIF1beta

Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KRAB-associated protein-1 (KAP1), is a protein that in humans is encoded by the TRIM28 gene.

Gene data

TRIM28

Name: tripartite motif containing 28
Type: protein-coding
Aliases: KAP1, PPP1R157, RNF96, TF1B, TIF1B, TIF1beta, WT7

The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008].

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Wikidata facts

Image: PDB 1fp0 EBI.jpg

Sources (4)

Article

13 sections

Contents

Function
Cellular differentiation and proliferation
Transcriptional regulation
DNA damage repair response
Apoptosis
Clinical significance
Role in the establishment of viral latency
Manipulations and potential for future treatment
Interactions
See also
References
Further reading
External links

== Function == The protein encoded by this gene mediates transcriptional regulation by interacting with the Krüppel-associated box (KRAB) repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. TRIM28 is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING finger domain, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM28 additionally possesses a domain that interacts with heterochromatin protein 1 (HP1) and a bromodomain capable of recognizing acetylated lysine residues in other proteins.