SETDB1

Also known as ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21, SET domain bifurcated 1, SET domain bifurcated histone lysine methyltransferase 1

Histone-lysine N-methyltransferase SETDB1 is an enzyme that in humans is encoded by the SETDB1 gene. SETDB1 is also known as KMT1E or H3K9 methyltransferase ESET.

Gene data

SETDB1

Name: SET domain bifurcated histone lysine methyltransferase 1
Type: protein-coding
Aliases: ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21

This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011].

via MyGene.info

Gene · Ensembl

SET domain bifurcated histone lysine methyltransferase 1

Symbol: SETDB1
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:150,926,263-150,964,748
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 32157
exact match: identifiers.org/ncbigene/9869
genomic end: 150937213
genomic start: 150898739
cytogenetic location: 1q21.3

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Function
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Histone-lysine N-methyltransferase SETDB1 is an enzyme that in humans is encoded by the SETDB1 gene. SETDB1 is also known as KMT1E or H3K9 methyltransferase ESET.

== Function == The human SETDB1 protein consists of multiple N-terminal and C-terminal functional domains linked by an intervening sequence of variable length, which can exist in multiple isoforms generated by alternative splicing.