corepressor
Sign in to saveAlso known as transcription corepressor
In genetics and molecular biology, a corepressor is a molecule that represses the expression of genes. In prokaryotes, corepressors are small molecules whereas in eukaryotes, corepressors are proteins. A corepressor does not directly bind to DNA, but instead indirectly regulates gene expression by binding to repressors.
~6 min read
Article
13 sectionsContents
- Function
- Prokaryotes
- Eukaryotes
- Examples of corepressors
- NCoR
- Silencing mediator for retinoid and thyroid-hormone receptor
- Role in biological processes
- Clinical significance
- Diseases
- Therapeutic Potential
- See also
- References
- External links
In genetics and molecular biology, a corepressor is a molecule that represses the expression of genes. In prokaryotes, corepressors are small molecules whereas in eukaryotes, corepressors are proteins. A corepressor does not directly bind to DNA, but instead indirectly regulates gene expression by binding to repressors.
A corepressor downregulates (or represses) the expression of genes by binding to and activating a repressor transcription factor. The repressor in turn binds to a gene's operator sequence (segment of DNA to which a transcription factor binds to regulate gene expression), thereby blocking transcription of that gene. thumb|Corepressor Transcription Factor Complex on Regulatory Element