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GeneQ18047615· pop 6· linked from 47 articles

LCOR

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Also known as MLR2, ligand dependent nuclear receptor corepressor, C10orf12

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.

Gene data

LCOR

Name: ligand dependent nuclear receptor corepressor
Type: protein-coding
Position: 96,831,803–96,995,956 (+)
Aliases: C10orf12, MLR2
Ensembl: ENSG00000196233
RefSeq RNA: NM_001170765.2, NM_001170766.2, NM_001346516.2, NM_015652.3, NM_032440.4
RefSeq protein: NP_001164236.1, NP_001164237.1, NP_001333445.1, NP_115816.2

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II heterochromatin formation cellular response to estradiol stimulus

Molecular function

transcription corepressor binding DNA binding transcription corepressor activity protein binding nuclear estrogen receptor binding histone deacetylase binding histone methyltransferase binding histone methyltransferase binding

Cellular component

nucleus nucleus nucleus nucleoplasm

via MyGene.info

Gene · Ensembl

ligand dependent nuclear receptor corepressor

Symbol: LCOR
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:96,831,803-96,995,956
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein LCOR PDB 2cob.png

Show 5 more facts

exact match: identifiers.org/ncbigene/84458
genomic end: 96995956
HomoloGene ID: 22914
genomic start: 96832254
cytogenetic location: 10q24.1

Sources (4)

via Wikidata · CC0

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Article

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Contents

Function
References
Further reading
External links

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.

== Function ==

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Categories

Genes on human chromosome 10 Transcription coregulators