NCOA1

Name

nuclear receptor coactivator 1

Type

protein-coding

Position

24,490,992–24,770,702 (+)

Aliases

F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74

Ensembl

ENSG00000084676

RefSeq RNA

NM_001362950.1, NM_001362952.1, NM_001362954.1, NM_001362955.1, NM_003743.5

RefSeq protein

NP_001349879.1, NP_001349881.1, NP_001349883.1, NP_001349884.1, NP_003734.3

The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].