STAT6
Sign in to saveAlso known as D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. Similarly as other STAT family proteins, STAT6 is also activated by growth factors and cytokines. STAT6 is mainly activated by cytokines interleukin-4 and interleukin-13.
Gene data
STAT6- Name
- signal transducer and activator of transcription 6
- Type
- protein-coding
- Position
- 57,095,404–57,132,139 (−)
- Aliases
- D12S1644, HIES6, IL-4-STAT, STAT6B, STAT6C
- Ensembl
- ENSG00000166888
- RefSeq RNA
- NM_001178078.2, NM_001178079.2, NM_001178080.2, NM_001178081.2, NM_001445504.1
- RefSeq protein
- NP_001171549.1, NP_001171550.1, NP_001171551.1, NP_001171552.1, NP_001432433.1
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
signal transducer and activator of transcription 6
- Symbol
- STAT6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:57,095,403-57,132,139
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 2373
- exact match
- identifiers.org/ncbigene/6778
- genomic end
- 57525922
- genomic start
- 57489191
- cytogenetic location
- 12q13.3
via Wikidata · CC0
~4 min read
Article
10 sectionsContents
- Gene
- Structure
- Regulation
- Function
- Clinical significance
- Interactions
- See also
- References
- Further reading
- External links
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. Similarly as other STAT family proteins, STAT6 is also activated by growth factors and cytokines. STAT6 is mainly activated by cytokines interleukin-4 and interleukin-13.
== Gene ==