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momelotinib
Sign in to saveAlso known as CYT-387, CYT387
Momelotinib, sold under the brand name Ojjaara among others, is an anticancer medication used for the treatment of myelofibrosis. It is a Janus kinase inhibitor and it is taken by mouth.
Chemical data
- Formula
- C23H22N6O2
- Molecular weight
- 414.5 g/mol
- IUPAC name
- N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2023
- Admin. routes
- oral
- Indications
- essential thrombocythemia, polycythemia vera, primary myelofibrosis, non-small cell lung carcinoma
via ChEMBL · EBI
Research
252 papers- SIMPLIFY-1: A Phase III Randomized Trial of Momelotinib Versus Ruxolitinib in Janus Kinase Inhibitor-Naïve Patients With Myelofibrosis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017
- Momelotinib.2006
- Momelotinib.2012
- Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM): results from an international, double-blind, randomised, controlled, phase 3 study.Lancet (London, England) · 2023
- Momelotinib for the treatment of myelofibrosis.Blood · 2024
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 414.18
- Has use
- medication
Show 4 more facts
- chemical formula
- C₂₃H₂₂N₆O₂
- canonical SMILES
- C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N
- subject has role
- protein kinase inhibitors
- medical condition treated
- myelofibrosis
via Wikidata · CC0
~2 min read
Encyclopedic overview
7 sectionsContents
- Medical uses
- Pharmacology
- Pharmacodynamics
- Society and culture
- Legal status
- References
- External links
{{Chembox | ImageFile = Momelotinib.svg | ImageClass = skin-invert-image | ImageSize = 255 | PIN = N-(Cyanomethyl)-4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzamide | OtherNames =
| Section1 =
Excerpted from Wikipedia’s “momelotinib” article, available under the CC BY-SA 4.0 licence.
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