TNFRSF14
Sign in to saveAlso known as ATAR, CD270, HVEA, HVEM, LIGHTR, TR2, tumor necrosis factor receptor superfamily member 14, TNF receptor superfamily member 14
protein-coding gene in the species Homo sapiens
Gene data
TNFRSF14- Name
- TNF receptor superfamily member 14
- Type
- protein-coding
- Position
- 2,554,244–2,565,382 (+)
- Aliases
- ATAR, CD270, HVEA, HVEM, LIGHTR, TR2
- Ensembl
- ENSG00000157873
- RefSeq RNA
- NM_001297605.2, NM_003820.4, XM_006711019.3, XM_011542383.3, XM_047433412.1
- RefSeq protein
- NP_001284534.1, NP_003811.2, XP_006711082.1, XP_011540685.1, XP_047289368.1
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology
Biological process
positive regulation of cytokine production involved in immune responsenegative regulation of T cell cytokine productionimmune response-regulating cell surface receptor signaling pathwayregulation of T cell tolerance induction to tumor cellimmune responsecell surface receptor signaling pathwayregulation of B cell proliferationT cell costimulation
Molecular function
Pathways
Cytokine-cytokine receptor interaction - Homo sapiens (human)Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)Herpes simplex virus 1 infection - Homo sapiens (human)Cytokine Signaling in Immune systemAdaptive Immune SystemAdaptive Immune SystemImmune SystemImmune SystemRegulation of T cell activation by CD28 familyRegulation of T cell activation by CD28 family
via MyGene.info
Gene · Ensembl
TNF receptor superfamily member 14
- Symbol
- TNFRSF14
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR1_1_CTG3:106,829-116,812
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TNFRSF14 PDB 1jma.png
Show 8 more facts
- HomoloGene ID
- 2833
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8764
- chromosome
- human chromosome 1
- genomic start
- 2487078
- genomic end
- 2496821
- cytogenetic location
- 1p36.32
- expressed in
- gastric mucosa
Sources (3)
via Wikidata · CC0