IL4R

Name

interleukin 4 receptor

Type

protein-coding

Position

27,313,462–27,365,558 (+)

Aliases

CD124, IL-4RA, IL4RA

Ensembl

ENSG00000077238

RefSeq RNA

NM_000418.4, NM_001008699.1, NM_001257406.2, NM_001257407.2, NM_001257997.2

RefSeq protein

NP_000409.1, NP_001244335.1, NP_001244336.1, NP_001244926.1, XP_005255365.1

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012].

via MyGene.info

Gene · Ensembl

interleukin 4 receptor

Symbol

IL4R

Biotype

Protein coding

Organism

Homo sapiens

Location

16:27,313,462-27,365,558

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein IL4R PDB 1iar.png

via Wikidata · CC0