TNFSF14

Name

TNF superfamily member 14

Type

protein-coding

Position

6,658,085–6,670,621 (−)

Aliases

CD258, HVEML, LIGHT, LTg

Ensembl

ENSG00000125735

RefSeq RNA

NM_001376887.1, NM_003807.5, NM_172014.3

RefSeq protein

NP_001363816.1, NP_003798.2, NP_742011.2

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

TNF superfamily member 14

Symbol

TNFSF14

Biotype

Protein coding

Organism

Homo sapiens

Location

19:6,658,085-6,670,621

Strand

Reverse (−)

Assembly

GRCh38