CDH1
Also known as Arc-1, CD324, CDHE, ECAD, LCAM, UVO, cadherin 1, BCDS1
Cadherin-1 or Epithelial cadherin (E-cadherin), is a protein that in humans is encoded by the CDH1 gene (not to be confused with the APC/C activator protein CDH1). Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene.
Gene data
CDH1- Name
- cadherin 1
- Type
- protein-coding
- Position
- 68,737,292–68,835,540 (+)
- Aliases
- Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM, UVO
- Ensembl
- ENSG00000039068
- RefSeq RNA
- NM_001317184.2, NM_001317185.2, NM_001317186.2, NM_004360.5
- RefSeq protein
- NP_001304113.1, NP_001304114.1, NP_001304115.1, NP_004351.1
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015].
Gene Ontology
Article
20 sectionsContents
- History
- Function
- Cell cycle
- Cell sorting during epithelial budding
- Cell sorting during gastrulation
- Cell migration
- Force transduction by E-cadherin
- Mechanism of action
- Interactions
- Clinical significance
- Cancer
- Metastasis
- EMT
- MET
- Examples
- Genetic and epigenetic control
- See also
- References
- Further reading
- External links
Cadherin-1 or Epithelial cadherin (E-cadherin), is a protein that in humans is encoded by the CDH1 gene (not to be confused with the APC/C activator protein CDH1). Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene.
== History == The discovery of cadherin cell-cell adhesion proteins is attributed to Masatoshi Takeichi, whose experience with adhering epithelial cells began in 1966. His work originally began by studying lens differentiation in chicken embryos at Nagoya University, where he explored how retinal cells regulate lens fiber differentiation. To do this, Takeichi initially collected media that had previously cultured neural retina cells (CM) and suspended lens epithelial cells in it. He observed that cells suspended in the CM media had delayed attachment compared to cells in his regular medium. His interest in cell adherence was sparked, and he moved on to examine attachment in other conditions such as in the presence of protein, magnesium, and calcium. At this point in 1970s, little was understood about the specific roles these ions played. Therefore, Takeichi's work in discovering calcium's role in cell-cell adhesion was highly transformative.