Also known as cluster of differentiation 1, Antigens, CD1
CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells. CD1 glycoproteins are structurally related to the class I MHC molecules, however, in contrast to MHC class 1 proteins, they present lipids, glycolipids and small molecules antigens, from both endogenous and pathogenic proteins, to T cells and activate an immune response.
Key facts
- Protein.Arm
- q
- Protein.Band
- 22
- Protein.Name
- CD1e molecule
- Protein.HGNCid
- 1638
- Protein.Symbol
- CD1E
- Protein.AltSymbols
- CD1
- Protein.EntrezGene
- 913
- Protein.OMIM
- 188411
- Protein.RefSeq
- NM_030893
- Protein.UniProt
- P15812
- Protein.Chromosome
- 1
- Protein.LocusSupplementaryData
- -q23
via Wikipedia infobox
Research
13,820 papersvia PubMed
~9 min read
Article
13 sectionsContents
- Types
- In humans
- Group 1
- Group 2
- Diagnostic relevance
- Structure
- CD1-lipid TCR interactions
- CD36 interactions
- In other animals
- Rodents
- Ruminants
- References
- External links
CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells. CD1 glycoproteins are structurally related to the class I MHC molecules, however, in contrast to MHC class 1 proteins, they present lipids, glycolipids and small molecules antigens, from both endogenous and pathogenic proteins, to T cells and activate an immune response.
T cells recognise CD1 using TCR αβ, γδ, or CD36 family members. T cells that are activated by CD1-antigen complexes are called CD1-restricted T cells. 10% of all αβ T lymphocytes in human peripheral blood are Cd1-restricted, out of which, the most abundant are the T cells specific for CD1c.