CDH2
Sign in to saveAlso known as CD325, CDHN, CDw325, NCAD, cadherin 2, ACOGS, ARVD14
Cadherin-2 also known as Neural cadherin (N-cadherin), is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325 (cluster of differentiation 325). Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including hu
Gene data
CDH2- Name
- cadherin 2
- Type
- protein-coding
- Position
- 27,932,879–28,178,024 (−)
- Aliases
- ACOGS, ADHD8, ARVD14, CD325, CDHN, CDw325, NCAD
- Ensembl
- ENSG00000170558
- RefSeq RNA
- NM_001308176.2, NM_001792.5, XM_011525788.1, XM_017025514.3, XM_054318138.1
- RefSeq protein
- NP_001295105.1, NP_001783.2, XP_011524090.1, XP_016881003.1, XP_054174113.1
This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
cadherin 2
- Symbol
- CDH2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:27,932,879-28,178,024
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CDH2 PDB 1ncg.png
Show 10 more facts
- HomoloGene ID
- 20424
- genetic association
- obesity
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1000
- genomic end
- 28177946
- genomic start
- 27932879
- chromosome
- human chromosome 18
- cytogenetic location
- 18q12.1
- expressed in
- middle temporal gyrus
- Commons category
- N-cadherin (neural)
via Wikidata · CC0
~7 min read
Encyclopedic overview
12 sectionsContents
- Structure
- Function
- Role in development
- Role in cardiac muscle
- Role in neurons
- Role in cancer metastasis
- Clinical significance
- Interactions
- See also
- References
- Further reading
- External links
Cadherin-2 also known as Neural cadherin (N-cadherin), is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325 (cluster of differentiation 325). Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including human dilated cardiomyopathy. Variants in CDH2 have also been identified to cause a syndromic neurodevelopmental disorder.
== Structure == Cadherin-2 is a protein with molecular weight of 99.7 kDa, and 906 amino acids in length. Cadherin-2, a classical cadherin from the cadherin superfamily, is composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherin-2, as well as other cadherins, interact with Cadherin-2 on an adjacent cell in an anti-parallel conformation, thus creating a linear, adhesive "zipper" between cells.
Excerpted from Wikipedia’s “CDH2” article, available under the CC BY-SA 4.0 licence.