CD1d molecule
Sign in to saveAlso known as antigen-presenting glycoprotein CD1d, HMC class I antigen-like glycoprotein CD1D, CD1D antigen, d polypeptide, differentiation antigen CD1-alpha-3, R3G1, CD1D, T-cell surface glycoprotein CD1d, thymocyte antigen CD1D
CD1D is the human gene that encodes the protein CD1d, a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are non-classical MHC proteins, related to the class I MHC proteins, and are involved in the presentation of lipid antigens to T cells. CD1d is the only member of the group 2 CD1 molecules.
Protein · UniProt
Antigen-presenting glycoprotein CD1d
- Gene
- CD1D
- Organism
- Homo sapiens (Human)
- Length
- 335 aa
- Molecular mass
- 37,717 Da
- Evidence
- 1: Evidence at protein level
Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells
Swiss-Prot (reviewed) · via UniProt
Research
2,258 papers- Small-Molecule Carbohydrate-Based Immunostimulants.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017
- Varicella Zoster Virus Downregulates Expression of the Nonclassical Antigen Presentation Molecule CD1d.The Journal of infectious diseases · 2024
- The lysophospholipid-binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids.Transfusion · 2021
- In silico identification and characterization of small molecule binding to the CD1d immunoreceptor.Journal of biomolecular structure & dynamics · 2025
- γδ T cell receptor recognition of CD1d in a lipid-independent manner.Nature communications · 2025
via PubMed
Wikidata facts
- Instance of
- protein
Show 2 more facts
- found in taxon
- Homo sapiens
- molecular function
- protein binding
via Wikidata · CC0
~4 min read
Encyclopedic overview
8 sectionsContents
- Biological significance
- Nomenclature
- Ligands
- Tetramers
- In obesity and type 2 diabetes
- References
- Further reading
- External links
CD1D is the human gene that encodes the protein CD1d, a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are non-classical MHC proteins, related to the class I MHC proteins, and are involved in the presentation of lipid antigens to T cells. CD1d is the only member of the group 2 CD1 molecules.
==Biological significance== CD1d-presented lipid antigens activate a special class of T cells, known as natural killer T (NKT) cells, through the interaction with the T-cell receptor present on NKT membranes. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and interleukin 4 production.
Excerpted from Wikipedia’s “CD1d molecule” article, available under the CC BY-SA 4.0 licence.