CELSR1

Also known as CDHF9, FMI2, HFMI2, ME2, ADGRC1, cadherin EGF LAG seven-pass G-type receptor 1, LMPHM9

Cadherin EGF LAG seven-pass G-type receptor 1, also known as flamingo homolog 2 or cadherin family member 9, is a protein that in humans is encoded by the CELSR1 gene.

In the Vinony graph

Vinony's link graph records 489 inbound references to CELSR1, and connects out to PubMed, Ensembl genome database project and cell surface receptor.

It is catalogued under topics including Adhesion G protein-coupled receptors, Chemokine receptors and Genes on human chromosome 22.

Vinony links it to 5 Wikipedia language editions.

Gene data

CELSR1

Name: cadherin EGF LAG seven-pass G-type receptor 1
Type: protein-coding
Position: 46,360,834–46,537,638 (−)
Aliases: ADGRC1, CDHF9, FMI2, HFMI2, LMPHM9, ME2, YNS
Ensembl: ENSG00000075275
RefSeq RNA: NM_001378328.1, NM_014246.4, XM_011530553.2, XM_011530554.3, XM_011530555.3
RefSeq protein: NP_001365257.1, NP_055061.1, XP_011528855.1, XP_011528856.1, XP_011528857.1

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

establishment of planar polarity neuron migration neural tube closure cell adhesion homophilic cell-cell adhesion cell surface receptor signaling pathway G protein-coupled receptor signaling pathway Rho protein signal transduction

Molecular function

transmembrane signaling receptor activity G protein-coupled receptor activity calcium ion binding

Cellular component

plasma membrane plasma membrane plasma membrane adherens junction membrane membrane

Pathways

GPCRs, Other Development of ureteric collection system

via MyGene.info

Gene · Ensembl

cadherin EGF LAG seven-pass G-type receptor 1

Symbol: CELSR1
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:46,360,834-46,537,638
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 7665
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9620
genomic end: 46537620
genomic start: 46756731
chromosome: human chromosome 22
cytogenetic location: 22q13.31

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Function
See also
References
External links
Further reading

Cadherin EGF LAG seven-pass G-type receptor 1, also known as flamingo homolog 2 or cadherin family member 9, is a protein that in humans is encoded by the CELSR1 gene.

== Function ==

Excerpted from Wikipedia’s “CELSR1” article, available under the CC BY-SA 4.0 licence.