CDH8

Also known as Nbla04261, cadherin 8

Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.

Gene data

CDH8

Name: cadherin 8
Type: protein-coding
Position: 61,647,242–62,037,035 (−)
Aliases: Nbla04261
Ensembl: ENSG00000150394
RefSeq RNA: NM_001410893.1, NM_001796.5, XM_005255760.5, XM_047433482.1, XM_047433484.1
RefSeq protein: NP_001397822.1, NP_001787.2, XP_005255817.1, XP_047289438.1, XP_047289440.1

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008].