CD22 molecule
Sign in to saveAlso known as BL-CAM, sialic acid-binding Ig-like lectin 2, CD22, B-lymphocyte cell adhesion molecule, B-cell receptor CD22, CD22 antigen, T-cell surface antigen Leu-14, Siglec-2
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
Protein · UniProt
B-cell receptor CD22
- Gene
- CD22
- Organism
- Homo sapiens (Human)
- Length
- 847 aa
- Molecular mass
- 95,348 Da
- Evidence
- 1: Evidence at protein level
Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow (PubMed:34330755, PubMed:8627166). Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration (PubMed:20172905). Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signalin…
Swiss-Prot (reviewed) · via UniProt
Research
1,180 papers- Reprogramming CD22 CAR-T cells in vivo using CD8-targeted mRNA-LNPs to treat hematological malignancies.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
- CD22 blockade modulates microglia activity to suppress neuroinflammation following intracerebral hemorrhage.Pharmacological research · 2023
- CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.Nature · 2019
- CD22 blockade exacerbates neuroinflammation in Neuromyelitis optica spectrum disorder.Journal of neuroinflammation · 2024
- CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy.Nature medicine · 2018
via PubMed
Wikidata facts
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- purl.uniprot.org/uniprot/P20273
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Article
12 sectionsContents
- Structure
- Extracellular part
- Trans ligands
- BCR signaling
- Inhibitory role
- Activation role
- Autoimmunity
- As a drug target
- Inotuzumab
- Interactions
- References
- External links
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice. In mice, it has been shown that CD22 blockade restores homeostatic microglial phagocytosis in aging brains. alt=|center|thumb|image of microglia